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For over 3 months now, I have been experiencing severe cramps in both legs and feet, sometimes in my arms and hands. They occur day and night. I discussed with my neuro and he seems to think it has to do with the combination of my current treatment (Rystiggo) and mestinon. He recommended decreasing my mestinon – saying he would like to wean me off of it completely. I’ve lowered the mestinon dosage; still having cramps in my legs and feet. I previously took potassium because I thought it would help but it didn’t. I suffer from frequent eye twitching that I also complained about. That has not subsided either.