Myasthenia Gravis News Community › Forums › Welcome Lounge › Pyridostigmine 180 SR shortage › Reply To: Pyridostigmine 180 SR shortage

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    Hi! I also usually take the 180 tabs, one in the morning and one in the late afternoon. I have seen some posts commenting on the 180 shortage. What I’m seeing is that some people do not realize that the 180 mg are an extended release dose. So, the 180s should never be broken or split, and the 60 mg tabs are not going to work the same. The 180 is formulated to give an even dose for an extended time (they need to be taken a minimum of 6 hours apart). The 3x60mg is giving you all of your dose that should last for several hours in one dose that will give you a BIG bump of medicine that will last a short time and then you will have a period of time where you are getting nothing. If you are taking 60s instead of 180s they need to be spaced out appropriately. So in my case I space the 60s out and take one every 2.5-3 hours. You can also use some discretion in spacing the 60s. Like if you are going out for something that will take more of your strength, space them out so you can take one shortly before leave (and bring a dose with depending on how long you’ll be gone).

    So if you are not spacing them out, please work with your doctor to get the 60s scheduled the best way for you.

    In my case the pharmacist had told me to just take 3 of them instead of the 180. But it’s a good thing I read everything I can about a new diagnosis or medication, so I knew not to. I would have been so sick! I can’t take 1×60 without eating or I will feel sick.