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After an MG flare, my Neuro started prednisone at 20mg and continued to up the dose as it was not having any effect (Mestinon reduced but did not eliminate symptoms) until it hit 80mg daily a year later. I had 2 PEs, a TIA, major cataracts, my A1C spiked well into diabetic territory, my weight ballooned, and I developed ape jowls. I switched Neuros and he immediately began tapering prednisone and put me on Cellcept. 1 1/2 years later, I still take Cellcept but am off all other MG meds and am symptom free with my A1C and weight back to perfectly normal.