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Here is what has worked for me. First thing is to identify other things that trigger a bowel movement. For me, excessive alcohol consumption which for the purpose of discussing diarrhea is more than one beer or drink for me. I now limit my drinking to either a Friday or Saturday night. Coffee can be an issue. Spicy food. I like my food HOT. Once again I prefer to indulge when I feel reasonably sure that I will have quick and unfettered access to a restroom. I always take my Mestinon immediately after a meal. Milk and ice cream have been greatly reduced to prevent lactose intolerance. In short, avoid the things that sometimes makes you go to the bathroom because it is only worse when you take Mestinon. I have found that increasing my fiber intake has helped. I usually try to eat an apple with my lunch. Fiber helps to bulk up and stabilize the stool and seems to stabilize the digestive track. As time has gone on, the diarrhea has become less and less. I hope my tips might help you or someone else. Good Luck.