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I started out at 30 mg a day when I was diagnosed 11 years ago and I gained 30 lbs within three months. Trying to cope with the diagnosis and the hungrier appetite was too much. Trying to diet during that period was not good. However, fast forward to this period of time and the lesser amount of prednisone 2.5 was the key. I was able to lose 60 lbs because timing was the key. Recently, my MG came out of remission and became active again when I had to take a large dose of prednisone for a procedure. So, my prednisone went up twice trying to fix that and the appetite is back. Drinking water seems to help but try to consume most of that in the AM or you will spend all night up and down going to the bathroom. I will tell you my previous weight loss was due to a program that had a structured diet and I paid a subscription to belong. Hope this gives you some hope.