Reply To: Actual Results using Vyvgart

[Community Member]

Hi Edward,

I was on IVIG every 3 weeks for the past 10 months.  When I got Vyvguard approval, I had to stop IVIG for 3-4 weeks before getting the first dose of Vyvguard.  I believe it is due to the mechanism of action (MOA) with the Vyvguard versus IVIG.  With IVIG you are getting infused with IgG antibodies to boost immune function, whereas with Vyvguard, the infusion consists of IgG1 antibody fragment that binds to the Fc receptor (FcRn) resulting in the reduction of circulating IgG levels and AChR antibody levels so essentially it cancels out the benefit of IVIG.  Hope this helps and you feel better!