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I think it’s critical that these studies state the specific material that is being smoked — tobacco is miles removed from cannabis. I’ve never smoked tobacco and haven’t had much exposure, aside from living in Cairo for 2 months (air is basically saturated with tobacco) leading up to the onset of MG at age 22; however, my mom’s father smoked throughout her childhood (epigenetics ??). To manage chronic pain, I’ve used cannabis regularly for 13 years without any adverse effects, even with exercise-induced asthma (at least to my knowledge).