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I have never smoked, nor has anyone in my close family. I was diagnosed at 17 years (now 78). When I was 22, two years after my thymectomy I worked for a scientific research organisation in Australia. I was reasonably well (maybe 6 x60mg Mestinon daily) but had a serious, but temporary exacerbation when exposed to nicotine sulphate which was used to “sterilise” cabinets for experiments. I recovered quickly but noticed in very smokey social environments I would become weak.