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Many of us are on prednisone which affects bone density if used long-term. That, of course, can lead to osteoporosis which increases the chance of bone fractures. So, the addition of calcium supplements when taking prednisone makes sense. I take this Over-the-Counter supplement (at my neurologist’s suggestion) twice daily: 600mg calcium+400IU of vitamin D3 in one tablet. (Vitamin D helps your body absorb calcium so, if it is not included in your calcium supplement, you may want to take it separately.) Though I do not take the B vitamins (B-6, B-12, folic acid) I have read that prednisone increases their loss from our bodies.