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Yes seronegative is a slippery slope but Theresa is seropositive, which means there is zero doubt that she has MG even if the medicine she does take does not work ( I know she is seropositive because vyvgart is only FDA approved for seropositive patients).I am sorry about your aunt but neurologists do not make the diagnosis of seronegative MG lightly with only a few ambiguous symptoms and no other tests, (some people wait for years for a diagnosis when they are seronegative )because they know the drugs used to treat it that are usually life saving drugs for most with the disease are harsh and come with a whole slew of side effects which is possibly what happened to your aunt or the disease progressed to point that put her in the wheelchair which can happen with MG even with treatment .