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Myasthenia Gravis News Community › Forums › Research and Clinical Trials › What happened to efgartigimod/Vyvgart for seronegative MG? › Reply To: What happened to efgartigimod/Vyvgart for seronegative MG?

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    Hi

    I would really like to reach out to this group to find out what is known about the non-responders to efgartigimod and nipocalimab.

    In phase 3 efgartigimod works for 68% (great news) but 32% it does not in gMG
    Likewise, in phase 2 nipocalimab works for 52% and 48% it does not.

    On non-responders is their a high baseline of IgG or have neutralising antibodies to the therapy started? Or something else?

    Any discussion greatly appreciated

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