Statins made my muscle cramps worse, caused spasticity, and made weakness much much worse. I get moderate muscle cramps with Mestinon but the two together caused painful muscle spasticity, and caused my hands to lock in cramped claw-like positions with cramping all the way up my arm. Similar problems with my legs. I am off statins and regulate my cholesterol with daily psyllium fiber which works great and lowered my numbers to optimal.